D-Panthenol
Pro-Vitamin B5, 100% Liquid
INCI: Panthenol · CAS 81-13-0 · D-Panthenol · 100% Liquid · Water Soluble
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D-Panthenol is a high-purity liquid form of Pro-Vitamin B5 for cosmetic formulation. Panthenol is converted within the skin to pantothenic acid (Vitamin B5), where it penetrates the outer layers of the skin to help support skin hydration and conditioning. Lightweight, water soluble, and effective at low concentrations across a wide range of applications.
100% liquid form — no dilution needed, easy to incorporate directly into the water phase. Suitable for skin care, hair care, and body care formulations. Non-greasy, well tolerated in cosmetic formulations, and compatible with a wide variety of cosmetic formulations.
| INCI Name | CAS | Function |
|---|---|---|
| Panthenol | 81-13-0 | Humectant, skin conditioner, hair conditioner, soothing, supports skin barrier |
| Property | Value |
|---|---|
| INCI name | Panthenol |
| CAS number | 81-13-0 |
| Appearance | Colorless to pale yellow, clear, viscous liquid |
| Concentration | 100% — undiluted |
| Solubility | Water soluble |
| Preservation | Preservative-free |
| Storage | Store in a cool, dry place away from light and heat in a sealed container |
| Certificate of Analysis | Download COA → |
| Spec Sheet | Download Spec Sheet → |
| Application | Usage Rate |
|---|---|
| Facial moisturizers and serums | 0.5–2% |
| Body lotions and creams | 1–5% |
| After-sun and soothing formulations | 1–5% |
| Shampoos and conditioners | 0.5–2% |
| Hair masks and treatments | 1–5% |
| Baby and sensitive skin products | 0.5–1% |
| Eye creams and serums | 0.5–1% |
- Add to the water phase — freely soluble in water at room temperature
- 100% liquid — no need to pre-dissolve, incorporate directly into the water phase
- Compatible with a wide variety of cosmetic formulations including AHA and BHA systems
- Panthenol is converted within the skin to pantothenic acid — penetrates the outer layers of the skin to help support skin hydration and conditioning
- Commonly used in after-sun and soothing formulations — helps calm dry skin and helps support the skin barrier at 1–5%
- In hair care, coats and penetrates the hair shaft — improves elasticity, reduces breakage, and controls frizz
- Pairs well with INCI VAULT's Allantoin for enhanced soothing and skin barrier support
- Pairs well with INCI VAULT's Hydroxyethyl Urea for a deep, non-tacky moisture system
- Intended use: Our products are provided for the exclusive purpose of creating external cosmetic and personal care formulations. They are not intended for internal use.
- Creator's liability: INCI VAULT is a supplier of ingredients and is not responsible for the final products you create. The responsibility for ensuring product safety, stability, and regulatory compliance rests entirely with you. This includes conducting thorough testing of all formulas.
- Professional guidance: If you do not have an advanced background in cosmetic science, we advise seeking the guidance of a professional formulator or chemist.
- FDA statement: The information and statements contained herein have not been evaluated by the Food and Drug Administration. These products are not designed to diagnose, treat, cure, or prevent any disease.
Need a larger quantity? Reach out — support@inci-vault.com
D-Panthenol (INCI: Panthenol · CAS 81-13-0 · also known as Dexpanthenol) is a high-purity 100% liquid form of Pro-Vitamin B5 — undiluted, water soluble, and ready to incorporate directly into the water phase. D-Panthenol is converted within the skin to pantothenic acid (Vitamin B5) to help support skin hydration and conditioning. Skin conditioner · humectant · hair conditioner · soothing · helps support skin barrier and recovery. Use at 0.5–5%. Preservative-free. Well tolerated. Suitable for skin, hair, and baby care formulations.
| What is D-Panthenol used for?A humectant, skin conditioner, and hair conditioner used at 0.5–5% in serums, moisturizers, body lotions, shampoos, conditioners, hair masks, after-sun, and baby care formulations. D-Panthenol is converted within the skin to pantothenic acid (Vitamin B5) to help support skin hydration and conditioning. |
| What is the difference between D-Panthenol and DL-Panthenol?D-Panthenol is the biologically active form — only the D isomer is converted to pantothenic acid in the skin. DL-Panthenol is a racemic mixture. INCI VAULT supplies D-Panthenol at 100% concentration, undiluted and preservative-free. |
| Why 100% liquid vs diluted versions?Undiluted — no added water or carrier. You control the exact concentration. Typical use level is 0.5–5% in finished formulations. |
| How does it benefit hair care?Coats and penetrates the hair shaft — improves elasticity, reduces breakage, controls frizz, and strengthens the hair cortex. Use at 0.5–2% in shampoos and conditioners and 1–5% in hair masks. |
| Is it suitable for sensitive skin?Yes — Panthenol is well tolerated and suitable for sensitive skin formulations. It is one of the most commonly used actives in baby care, after-sun, and sensitive skin formulations. Use at 0.5–1% in baby and sensitive skin products. |
| How is it incorporated?Add directly to the water phase at room temperature. No pre-dissolving needed. Compatible with a wide variety of cosmetic formulations including AHA and BHA systems. |
Note: D-Panthenol is undiluted Pro-Vitamin B5 — add directly to the water phase, no pre-dissolving required. At 0.5–2% it delivers skin hydration and conditioning. At 2–5% it provides meaningful soothing and helps support the skin barrier and recovery. In hair care, it coats and penetrates the hair shaft for measurable improvements in elasticity and frizz control. Pairs well with INCI VAULT's Allantoin for enhanced soothing and barrier support, and with INCI VAULT's Hydroxyethyl Urea for a deep, non-tacky moisture system.
