Matrixyl 3000 Peptide
Anti-Wrinkle Matrikine Active
Palmitoyl Tripeptide-1 · Palmitoyl Tetrapeptide-7 · Pal-GHK & Pal-GQPR · Water Soluble
Need a larger quantity? Reach out — support@inci-vault.com
Matrixyl 3000 Peptide is a clinically proven anti-wrinkle active combining two palmitoylated matrikines — Palmitoyl Tripeptide-1 (Pal-GHK) and Palmitoyl Tetrapeptide-7 (Pal-GQPR). These messenger peptides activate genes involved in extracellular matrix renewal, supporting the skin's repair process at the level of the papillary dermis.
Water soluble · preservative-free · effective at 3% · patented technology
| Component | Function |
|---|---|
| Glycerin | Humectant, carrier |
| Aqua (Water) | Solvent |
| Butylene Glycol | Humectant, solvent |
| Carbomer | Stabilizer |
| Polysorbate 20 | Solubilizer |
| Palmitoyl Tripeptide-1 (Pal-GHK) | Matrikine — ECM renewal, collagen stimulation |
| Palmitoyl Tetrapeptide-7 (Pal-GQPR) | Matrikine — anti-inflammatory, dermal repair |
| Measure | Matrixyl 3000 | Placebo |
|---|---|---|
| Surface of deep wrinkles | −39.4%** | +4.3ns |
| Main wrinkle density | −32.9%** | −9.9ns |
| Main wrinkle average depth | −19.9%** | −3.2ns |
| Main wrinkle average volume | −23.3%** | −8.7* |
| Roughness | −16.0%** | −1.4ns |
| Elasticity | +5.5%* | +4.1ns |
| Skin tone | +15.5%** | +6.5ns |
| Property | Value |
|---|---|
| Form | Liquid solution |
| Solubility | Water soluble |
| Preservation | Preservative-free |
| Use level | 3% |
| Applications | Anti-wrinkle products — face creams, serums, eye creams, makeup |
- Water soluble — add to the water phase of emulsions or directly to aqueous serums
- Use at 3% for full anti-wrinkle clinical efficacy as demonstrated in vivo
- Preservative-free — compatible with sensitive skin formulations
- Ideal for face creams, serums, eye creams, anti-aging treatments, and makeup bases
- Works by activating matrikine receptors to stimulate ECM renewal — not a surface filler
- Regulates progerin (a senescence marker) — helping ageing skin behave more like young skin
- Intended use: Our products are provided for the exclusive purpose of creating external cosmetic and personal care formulations. They are not intended for internal use.
- Creator's liability: INCI VAULT is a supplier of ingredients and is not responsible for the final products you create. The responsibility for ensuring product safety, stability, and regulatory compliance rests entirely with you. This includes conducting thorough testing of all formulas.
- Professional guidance: If you do not have an advanced background in cosmetic science, we advise seeking the guidance of a professional formulator or chemist.
- FDA statement: The information and statements contained herein have not been evaluated by the Food and Drug Administration. These products are not designed to diagnose, treat, cure, or prevent any disease.
Need a larger quantity? Reach out — support@inci-vault.com
Matrixyl 3000 Peptide (INCI: Glycerin, Aqua, Butylene Glycol, Carbomer, Polysorbate 20, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7) is a clinically proven anti-wrinkle matrikine active. At 3%, it has been shown to reduce deep wrinkles by 39.4%, improve skin tone by 15.5%, and deliver a −5.5 year age gain in the dermis after 2 months.
- Anti-wrinkle face creams and serums (3%)
- Eye creams and treatments for periorbital wrinkles
- Anti-aging moisturizers and night creams
- Neck and décolletage treatments
- Water soluble — add to the water phase
- Preservative-free — compatible with sensitive skin formulations
- Activates ECM renewal — works at the dermal level, not a surface filler
- Regulates progerin to help ageing skin behave like young skin
| What is Matrixyl 3000 Peptide used for?Used as an anti-wrinkle active in face creams, serums, and eye creams. Activates extracellular matrix renewal to reduce wrinkles and improve skin tone and elasticity. |
| How do matrikines work?Matrikines are messenger peptides that interact with cell receptors to activate genes involved in ECM renewal and cell proliferation — mechanisms that weaken with age. Matrixyl 3000 re-activates them. |
| What is the clinical efficacy?At 3% over 2 months: −39.4% deep wrinkle area, −32.9% wrinkle density, +15.5% skin tone, +5.5% elasticity vs baseline — all significant vs placebo. Age gain of −5.5 years in dermis. |
| What percentage should be used?3% — the concentration used in all clinical studies. |
| Is it water soluble?Yes — water soluble and preservative-free. Add to the water phase of emulsions or directly into aqueous serums. |
Note: Water soluble — add to the water phase. Use at 3% for full clinical efficacy. Preservative-free. Works at the dermal level by activating matrikine receptors — not a surface filler. Regulates progerin (−27%) and SA β-galactosidase (−56%), helping ageing skin behave more like young skin.
