Allantoin Powder
Skin Soother & Moisturizing Active
INCI: Allantoin · CAS 97-59-6 · USP Grade · 99–101% Purity · Crystalline Powder · Water Soluble
Need a larger quantity? Reach out — support@inci-vault.com
Allantoin is a naturally occurring compound and a highly effective skin active used across a wide range of cosmetic formulations. At concentrations as low as 0.1%, it soothes irritated skin, promotes softens the stratum corneum, and helps the skin retain moisture. Non-irritating, non-sensitizing, and compatible with virtually every cosmetic system.
99–101% purity · crystalline powder · water soluble · preservative-free · suitable for sensitive skin · widely used in moisturizers, serums, toners, lip care, and after-sun formulations.
| INCI Name | CAS | Function |
|---|---|---|
| Allantoin | 97-59-6 | Skin conditioner, soothing agent, moisturizer |
| Property | Value |
|---|---|
| Appearance | White crystalline powder, odorless |
| INCI name | Allantoin |
| CAS number | 97-59-6 |
| Purity grade | USP grade · 99–101% |
| Composition | Allantoin |
| Melting point | 225°C |
| Solubility | Water soluble — approx. 1g/200ml. Problematic to dissolve if concentration exceeds 0.5%. Dissolves faster in warm water at 70–80°C. |
| pH stability | Stable at pH 3–8 |
| Preservation | Preservative-free |
| Storage | Store light-protected at a cool and dry place |
| Raw material source | Glyoxylic acid and urea |
| Manufacturing method | Synthetically produced by direct condensation of glyoxylic acid and urea |
| Animal testing | Not animal tested |
| GMO status | GMO-free (does not contain plant-derived components) |
| Vegan status | Vegan — does not contain animal-derived components |
| HS Code | 2933210010 |
| FDA regulatory status | Registered as an OTC skin protectant drug (Category I · allowed concentration 0.5–2%). If skin protectant claims are made on the label, Allantoin must be listed under Active Ingredients and the facility and product must be registered with the FDA under cGMP. If no skin protectant claims are made, no registration is required. |
| Prop 65 | This product contains a chemical known to the State of California to cause cancer, birth defects, or other reproductive harm |
| Certificate of Analysis | Download COA → |
| Application | Usage Rate |
|---|---|
| Facial moisturizers and serums | 0.1–1% |
| Toners and essences | 0.1–0.5% |
| Body lotions and creams | 0.1–2% |
| Lip care — balms and treatments | 0.1–1% |
| After-sun and soothing formulations | 0.5–2% |
| Shampoos and scalp treatments | 0.1–0.5% |
| Sensitive skin formulations | 0.1–0.5% |
- Add to the water phase — dissolves slowly in cold water, faster at 70–80°C
- Use at 0.1–2% — effective at very low concentrations, no need to exceed 2% in most applications
- Stable across a wide pH range (3–8) — compatible with acidic and neutral formulations including AHA and BHA systems
- Excellent pairing with INCI VAULT's SaliSolv SA — Allantoin counteracts potential irritation of salicylic acid for a more balanced, skin-friendly formulation
- Works well alongside Hydroxyethyl Urea for enhanced moisture retention and skin barrier support
- Suitable for rinse-off and leave-on formulations — shampoos, conditioners, cleansers, serums, creams
- Non-sensitizing and non-irritating — ideal for sensitive, reactive, and post-procedure skin formulations
- Intended use: Our products are provided for the exclusive purpose of creating external cosmetic and personal care formulations. They are not intended for internal use.
- Creator's liability: INCI VAULT is a supplier of ingredients and is not responsible for the final products you create. The responsibility for ensuring product safety, stability, and regulatory compliance rests entirely with you. This includes conducting thorough testing of all formulas.
- Professional guidance: If you do not have an advanced background in cosmetic science, we advise seeking the guidance of a professional formulator or chemist.
- FDA statement: The information and statements contained herein have not been evaluated by the Food and Drug Administration. These products are not designed to diagnose, treat, cure, or prevent any disease.
Need a larger quantity? Reach out — support@inci-vault.com
Allantoin (INCI: Allantoin · CAS 97-59-6 · 99–101% purity) is a white crystalline powder used as a skin soothing active, and moisturizer in cosmetic formulations. Effective at 0.1–2%. Water soluble. Stable at pH 3–8. Non-irritating, non-sensitizing. Compatible with AHA, BHA, and sensitive skin formulations. Melting point 225°C. Preservative-free.
- Facial moisturizers and serums — 0.1–1% for soothing, and moisture retention
- Toners and essences — 0.1–0.5% for gentle active delivery
- After-sun and soothing formulations — 0.5–2% for calming and skin repair
- Lip care — 0.1–1% for conditioning and healing
- Shampoos and scalp treatments — 0.1–0.5% for scalp soothing
- Pairs with SaliSolv SA — counteracts potential salicylic acid irritation for balanced BHA formulations
- Pairs with Hydroxyethyl Urea — enhanced moisture retention and skin barrier support
- Add to water phase — dissolves in warm water at 70–80°C
| What is Allantoin used for?A skin soothing active, and moisturizer. At 0.1%, soothes irritation, promotes softens the stratum corneum, and supports moisture retention. Non-irritating, non-sensitizing, suitable for sensitive skin. |
| How is it incorporated?Add to the water phase. Dissolves slowly in cold water, faster at 70–80°C. Stable at pH 3–8. |
| Is it suitable for sensitive skin?Yes — non-irritating and non-sensitizing. One of the most suitable actives for sensitive, reactive, and post-procedure skin. Counteracts irritation from salicylic acid and retinoids. |
| Can it be combined with salicylic acid?Yes — pairs well with SaliSolv SA. Counteracts potential irritation for a more balanced BHA formulation. |
| What is the purity?99–101% · white crystalline powder · melting point 225°C · preservative-free · COA available. |
Note: Allantoin is one of the most versatile and underutilized actives in cosmetic formulation. At just 0.1–0.5% it delivers measurable soothing and skin soothing benefits without affecting formulation aesthetics. For acne and BHA formulations, combine with INCI VAULT's SaliSolv SA — the Allantoin offsets irritation while maintaining the exfoliating efficacy of the salicylic acid. For high-performance hydration systems, pair with INCI VAULT's Hydroxyethyl Urea for a deeply moisturizing, skin barrier supporting combination.
